United States leadership in Strategic Missions, Electronic Warfare, and assured, advanced microelectronics is critical to military dominance and economic sovereignty. Loss of this leadership position threatens U.S. ability to deter adversaries and prevail in conflict. There are additional potential impacts to economic/industrial base equities extending beyond national security. The Naval Surface Warfare Center (NSWC), Crane Division, and the Department of Defense (DoD) require innovative technological solutions to address current and future security threats in the electromagnetic spectrum (EMS), trusted microelectronics, and strategic missions hardware environments. To engage the broadest set of innovators, NSWC Crane has created the Strategic and Spectrum Missions Advanced Resilient Trusted Systems (S2MARTS) OTA. The S2MARTS OTA (pronounced “SMARTS”) will refine strategies, management planning activities, and implement integrated, complementary solutions that enable broader Department of Defense (DoD) access to commercial state-of-the-art EMS technologies, advanced microelectronics, radiation-hardened (RAD-HARD) and strategic missions hardware.